Porphyrins

ABSTRACT

The invention comprises new compositions of matter, which are iron, manganese, cobalt or ruthenium complexes of porphyrins having hydrogen, haloalkyl or haloaryl groups in meso positions, two of the opposed meso atoms or groups being hydrogen or haloaryl, and two of the opposed meso atoms or groups being hydrogen or haloalkyl, but not all four of the meso atoms or groups being hydrogen. The invention also comprises new compositions of matter in which all four of the meso positions are substituted with haloalkyl groups and the beta positions are substituted with halogen atoms. A new method of synthesizing porphyrinogens is also provided. 
     The novel compositions and others made according to the process of the invention are useful as hydrocarbon conversion catalysts; for example, for the oxidation of alkanes and the decomposition of hydroperoxides.

The government of the United States of America has rights in thisinvention pursuant to Cooperative Agreement No. DE-FC21-90MC26029awarded hy the U.S. Department of Energy.

This application is a continuation in part of pending application Ser.No. 07/568,116 filed Aug. 16, 1990, which was a continuation in part ofapplication Ser. No. 07/425,089, filed Oct. 23, 1989, and now abandoned,which was a continuation in part of application Ser. No. 07/066,666,filed Jun. 26, 1987, now U.S. Pat. No. 4,900,871, which was acontinuation in part of application Ser. No. 07/000,246, filed Jan. 2,1987, now U.S. Pat. No. 4,895,682.

BACKGROUND OF THE INVENTION AND PRIOR ART

Electron deficient metalloporphyrins 1 (e.g. R=C₆ F₅, X=F,C1,Br,M=Fe)have been shown to be efficient catalysts for the highly selective airoxidation of light alkanes to alcohols (Ellis and Lyons, Cat. Lett., 3,389, 1989; Lyons and Ellis, Cat, Let 8, 45, 1991; U. S. Pat. Nos.4,900,871; 4,970,348), as well as for efficient decomposition of alkylhydroperoxides (Lyons and Ellis, J. Catalysis, 141, 311, 1993; Lyons andEllis, U.S. Pat. No. 5,120,886).

They are prepared by co-condensation of pyrrole with the appropriatealdehyde (Badger, Jones and Leslett, "Porphyrins VII. The Synthesis ofPorphyrins By the Rothemund Reaction", Aust.J.Chem., 17, 1028-35, 1964;Lindsey and Wagner, "Investigation of the Synthesis of Ortho-SubstitutedTetraphenylporphyrins", J. Org. Chem., 54,828, 1989; U.S. Pat. Nos.4,970,348; 5,120,882) followed by metal insertion (Adler, Longo, Kampasand Kim, "On the preparation of metalloporphyrins", J. Inorg.Nucl.Chem.,32, 2443, 1970) and β-halogenation; (U.S. Pat. Nos. 4,8.92,941;4,970,348). Ellis and Lyons U.S. Pat. No. 4,970,348 discloses chromiumcomplexes of meso-tetrakis(trifluoromethyl)beta-haloporphyrins, made byreacting pyrrole with trifluoroacetaldehyde, and halogenating theresulting porphyrin; also, azide and hydroxide complexes of theporphyrins. Ellis and Lyons U.S. Pat. No. 5,120,882 discloses iron andother metal complexes ofmeso-tetrakis(trifluoromethyl)-beta-nitro-porphyrins, obtained bynitration of meso-tetrakis(trifluoromethyl)porphyrin. ##STR1##

Dipyrromethanes (2; see J. D. Paine in "The Porphyrins" D. Dolphin, Ed.,Academic Press, New York, Vol. I, pages 101 and 163-234, 1978) are themost commonly used precursors to a wide variety of symmetrical andunsymmetrical porphyrins. The use of dipyrromethanes for the synthesisof porphyrins carrying electron-withdrawing groups in all peripheralpositions has been limited by the inaccessibility of 5,5'-unsubstituteddipyrromethanes in which the groups (2; R²,R³,R⁵,R⁶) that become thebeta positions, and the group (2;R⁴) that becomes the meso positions, ofthe resulting porphyrins, either electron-withdrawing or hydrogen forappropriate post-cyclization functionalization. ##STR2##

Acid-catalyzed co-condensation of 5,5-unsubstituted dipyrromethanes 3with aldehydes 4 has been shown to give porphyrins (5; M=2H) in highyield. However, since the precursor dipyrromethanes 3 used in thesedisclosures are beta alkyl meso-unsubstituted systems (R¹ =R² =R⁴ =R⁵=alkyl; R³ =H) and the aldehydes are aromatic aldehydes (R⁶ =aryl), theresulting porphyrins 5 are 5,15-diaryl-10,20 unsubstituted porphyrinswith alkyl substitution at the beta positions (R¹ =R² =R⁴ =R⁵ =alkyl)(Ogoshi, Sugimoto, Nishiguchi, Watanabe, Matsuda and Yoshida, "Synthesesof 5-Aryl and 5,15-diaryl-2,3,7,8,12,13,17,18 Octaethylporphines"Chemistry Lett., p.29, 1978; Gunter and Mander, "Synthesis andAtropisomer Separation of Porphyrins Containing Functionalization at the5,15-Meso Positions: Application to the Synthesis of Binuclear LigandSystems", J. Org. Chem., 46, 4792, 1981; Young and Chang, "Synthesis andCharacterization of Blocked and Ligand-Appended Hemes Derived fromAtropisomeric meso Diphenylporphyrins", J. Am. Chem. Soc." 107,898,1985; Osuka, Nagata, Kobayashi and Maruyama, "An Improved Synthesis of5,15-Diaryloctaalkylporphyrins', J. Heterocyclic Chem., 27, 1657, 1990).

The fully unsubstituted dipyrromethane 3 (R¹ =R² =R^(3=R) ⁴ =R⁵ =H) hasalso been condensed with substituted aromatic aldehydes 4 to givebeta-unsubstituted 5,15-diarylporphyrins which are also unsubstituted atthe other two meso positions 10 and 20 (5 R¹ =R² =R³ =R⁴ =R⁵ =H; R⁶=aryl); Manka and Lawrence, "High Yield Synthesis of5,15-Diarylporphyrins", Tetrahedron Lett., 30, 6989, 1989). ##STR3##

M. Homma et al, Tetrahedron Lett. 24, 4343 (1983) disclose Cu, Zn and Cocomplexes of porphyrins containing trifluoromethyl groups in β (beta)positions, such as1,3,5,7-tetrakis(trifluoromethyl)-2,4,6,8-tetraethylporphyrin.

N. Ono et al, Bull.Chem.So.Jpn. 62, 3368 (1989) also disclose zinccomplexes of porphyrins containing trifluoromethyl groups in βpositions, for example1,3,5,7-tetrakis(trifluoromethyl)-2,4,6,8-tetramethylporphyrin.

Hoffman, Robert and Meunier, "Preparation and catalytic activities ofthe manganese and iron derivatives of Br₈ TMP and C1₁₂ TMP, two robustporphyrin ligands obtained by halogenation of tetramesitylporphyrin',Bull.Soc.Chim.Fr., 129, 85, 1992, disclose ionic halogenation oftetramesitylporphyrin by N-bromosuccinimide or N-chlorosuccinimide togive as main product, meso-tetramesityl β-octabromoporphyrin andmeso-tetrakis(3-chloro-2,4,6-trimethylphenyl-β-octachloroporphyrin,respectively, and that manganese and iron derivatives of these porhyrinsare efficient catalysts for olefin epoxidation and alkane hydroxylation.

Lyons and Ellis, "Selective Low Temperature Hydroxylation of Butane ByMolecular Oxygen Catalyzed By an Iron Perhaloporphyrin Complex",Catalysis Lett., 8, 45, 1991 disclose synthesis of irontetrakis(pentafluorophenyl) β-octabromoporphyrinato complexes, havingunprecedented catalytic activity for the reaction of molecular oxygenwith isobutane to give tert-butyl alcohol.

Bhyrappa and Krishnan, "Octabromotetraphenylporphyrin and Its MetalDerivatives: Electronic Structure and Electrochemical Properties",Inorg.Chem., 30, 239, 1991 disclose V^(IV) O, Co(II), Ni(II), Cu(II),Zn(II), Pd(II), Ag(II) and Pt(II) derivatives ofoctabromotetraphenylporphyrin, and their electronic structure andelectrochemical properties.

Onaka, Shinoda, Izumi and Nolen, "Porphyrin Synthesis in ClayNanospaces", Chemistry Lett., 117, 1993 disclose synthesis ofmeso-tetraalkylporphyrins from aliphatic aldehydes and pyrroles by usingthe clay, montmorillonite.

Gong and Dolphin, "Nitrooctaethylporphyrins: synthesis, optical andredox properties", Can.,J.Chem, vol. 63, 1985, pages 401-5, disclosereaction of zinc octaethylporphyrin with N₂ O₄ in dichloromethane togive, in a stepwise reaction, the zinc complexes of mono-, di-, tri- andtetra-nitrooctaethylporphyrins, and demetallation of the products underacidic conditions to give the corresponding free base. The meso-nitrogroups exert steric and electronic effects on the porphyrin macrocycle.N-protonation of the nitrated species causes a distortion of the ringand gives an optical spectrum similar to that of protonated meso-arylsubstituted porphyrins. The nitro groups make the oxidation of theporphyrin ring more difficult and facilitate the ring reductions.

DESCRIPTION OF THE INVENTION

The present invention provides access for the first time to novelcatalytically active metalloporphyrins carrying perhalocarbyl groups attwo opposite meso positions (e.g.5,15) and which may also have otherelectron-withdrawing groups (perhalocarbyl, nitro) at the other two meso(10,20) positions. The novel catalysts of the invention are highlyactive for both alkane hydroxylation and hydroperoxide decomposition.The invention enables the synthesis of a series of catalytically active,highly electron deficient 5,15-(bis)halocarbyl metalloporphyrins withthe 10,20 meso positions unsubstituted or carrying electron-withdrawinggroups.

Since the syntheses provided by the invention may usemeso-substituted-beta-unsubstituted dipyrromethanes (e.g. 3; R¹ =R² =R⁴=R⁵ =H;R³ =halocarbyl), porphyrins 5 produced by co-condensation withappropriate aldehydes will in one embodiment of the invention carryelectron-withdrawing groups in all four meso positions, while the betapositions will still be available for substitution by otherelectron-withdrawing groups. By using R⁶ =H (HCHO or syntheticequivalent), 10,20-diunsubstituted porphyrins (5; R¹ =R² =R₄ =R⁵ =R⁶ =H;R³ =halocarbyl) are synthesized, which can be substituted byelectron-withdrawing groups (e.g. halogen, nitro). Any unsubstitutedbeta position on the porphyrin macrocycle can then be halogenated ornitrated according to known methods.

The invention comprises the following embodiments:

Method for synthesizing porphyrins by condensing a 5,5'-unsubstituteddipyrromethane (3; R³ is H or halocarbyl) with formaldehyde or itsequivalent or with a halocarbyl aldehyde (4; R⁶ is H or halocarbyl). Theproduct obtained where 3:R³ and 4:R⁶ are both hydrogen is ameso-unsubstituted porphyrinogen, which is subsequently converted to ameso-unsubstituted porphyrin. Where 3:R³ and 4:R⁶ are hydrogen andhalocarbyl respectively, and when 3:R³ and 4:R⁶ are halocarbyl andhydrogen respectively, the product is a meso-halocarbylporhyrinogenhaving halocarbyl groups at two opposite meso positions (e.g.5,15) andhydrogen at the other two meso (10,20) positions. Where 3:R³ and 4:R⁶are both halocarbyl, the product is ameso-tetrakis(halocarbyl)porphyrinogen. Where the product, afterconversion of the porphyrinogen is porphine ormeso-bis-hydrocarbylporphyrin, the meso hydrogens may be subsequentlysubstituted with electron-withdrawing groups such as halogen, nitro orcyano substituents.

New compositions of matter comprising catalytically active iron,manganese, cobalt or ruthenium complexes of porphyrins having hydrogenor haloaryl at two opposite meso positions (5; R³) and hydrogen orhaloalkyl at the other two opposite meso positions (5; R⁶) havinghydrogen, halogen, nitro, cyano or halocarbyl at beta positions; andazide derivatives, oxo-bridged dimer derivatives of such complexes.

"Halocarbyl' as the term is used herein includes halohydrocarbyl andperhalocarbyl. "Perhalocarbyl" as used herein refers to completesubstitution of halogen for hydrogen, or as near complete substitutionas reasonably possible to attain under the circumstances.

Methods of Synthesizing Porphines

The invention in one embodiment provides novel methods for synthesizingporphyrins in which a dipyrromethane having formula 3 where R³ ishydrogen or halocarbyl, preferably perhalocarbyl, for exampletrifluoromethyl, heptafluoropropyl, and R¹, R², R⁴, and R⁵ areindependently hydrogen, alkyl, halogen, nitro, cyano or halocarbyl, isreacted with an aldehyde, R⁶ CHO, where R⁶ is hydrogen or halocarbyl,preferably perhalocarbyl, for example pentafluorophenyl ortrifluoromethyl, under co-condensation conditions to produce anintermediate porhyrinogen, and said intermediate porphyrinogen isconverted to a meso-unsubstituted porphyrin (5; R³ =R⁶ =H) or to aporphyrin having halocarbyl groups in all four meso positions (5; R³=halocarbyl, R⁶ =halocarbyl).

Where the beta positions of the porphyrin are unsubstituted in the abovesynthesis, that is, where R¹, R² R⁴ and R⁵ are hydrogen, the betahydrogen atoms are available for substitution by electron-withdrawingatoms or groups such as halogen, nitro or cyano.

In another embodiment, in which the porphyrin produced has twohalocarbyl groups in meso positions, and the other two meso positions(10,20) are unsubstituted, prepared by using in the condensation ahalocarbyldipyrrcmethane (3; R³ =halocarbyl, for exampletrifluoromethyl, heptafluoropropyl)) and an aldehyde 4 in which R⁶ =H(HCHO or synthetic equivalent), porphyrins (5; R¹ =R² =R⁴ =R⁵ =R⁶ =H; R³=halocarbyl) are obtained, which can be subsequently substituted in thetwo free meso positions by electron-withdrawing atoms and groups (5; R⁶is halogen, NO2, CN.

In the method according to this embodiment of the invention, thedipyrromethane and aldehyde are contacted with an acid catalyst, forexample trifluoroacetic acid, hydrobromic acid or an insoluble acid suchas clay, for example montmorillonite K-10, under co-condensationconditions. Conditions are used in the co-condensation which are withinthe knowledge of the person skilled in the art of co-condensation ofdipyrromethanes and aldehydes.

Iron, manganese, cobalt and ruthenium, and particularly iron complexesof the porphyrins produced by the method of the invention are highlyactive catalysts for the hydroxylation of alkanes. Chromium complexes ofthe porphyrins produced by the method of this invention are disclosed inEllis et al U.S. Pat. 4,970,348 above as catalysts for the oxidation ofbutane to methylethylketone; secondary butyl alcohol is disclosed as aminor product of the oxidation. For partial oxidation of alkanes toalcohols, the iron, cobalt, manganese and ruthenium complexes accordingto the invention are superior to the chromium complexes of said patent.

New Compositions of Matter

The invention also comprises embodiments wherein new compositions ofmatter having the structural formula 5 above, where R⁶ is hydrogen orhaloaryl, R³ is hydrogen or haloalkyl, and R¹, R² , R⁴ and R⁵ areindependently hydrogen, halogen, nitro, cyano or halocarbyl, and Mcomprises iron, manganese, cobalt or ruthenium.

The invention also comprises new compositions of matter having theformula 5 where R³ and R⁶ are halocarbyl, R¹, R², R⁴ and R⁵ are halogenand M comprises iron, manganese, cobalt or ruthenium. These are metalcomplexes of perhalogenated meso tetraalkylporphyrins.

The new compositions of matter according to the invention include:

(1) the Fe, Mn, Co and Ru complexes ofmeso-bis(haloaryl)-bis(haloalkyl)porphyrins (5; M is M' or M'X, whereM'=Fe, Mn, Co or Ru and X=halogen or hydroxyl, R¹, R², R⁴ and R⁵ areindependently hydrogen, halogen, nitro, cyano or halocarbyl, R⁶ ishaloaryl and R³ is haloalkyl);

(2) the Fe, Mn, Co and Ru complexes of meso-tetrahalocarbyl-beta-perhaloporphyrins 5; M is as in (1) above, R³ and R⁶ arehalocarbyl and R¹, R², R⁴ and R⁵ are halogen);

(3) azide derivatives of substituted porphyrin metal complexes (MPN₃,where MP is a metal complex of a substituted porphyrin as disclosed in(1));

(4) oxo-bridged dimers of substituted porphyrin metal complexes asherein disclosed (MPOPM, where MP and PM are metal complexes ofsubstituted porphyrins as disclosed in (1)).

Examples of the above categories include the porphyrins synthesized inExamples 2, 3, 4, 5, 8, 16 and 17 below, namely:

5,15-bis(pentafluorophenyl)-10,20-bis-(trifluoromethyl)-porphyrin(Example 2),

the iron(III)chloride complex (Example 3) of the porphyrin of Example 2,

the oxo-bridged dimer (Example 4) of the complex of Example 3,

the azide derivative (Example 5) of the complex of Example 3,

di(trifluoromethyl)porphyrin (Example 8),

bis(pentafluorophenyl)-10,20-(trifluoromethyl)-β-octabromoporphyrinatoiron(III)(Example 16)

5, 10,15,20-tetrakis(trifluoromethyl)porphyrinatoiron(III) chloride(Example 17)

Following the co-condensation of dipyrromethane with aldehyde accordingto the invention, transition metal such as iron may be inserted into theporphyrins to prepare the catalytic species in their hemin, azide oroxo-bridged dimer forms. Where feasible, the hydroxide forms are alsowithin the scope of the invention. Further modification of theporphyrins by substitution at the beta and meso positions with otherelectron-withdrawing groups (halogens, nitro, etc.) may be done beforeor after insertion of iron or other transition metal. The products havehighly efficient catalytic behavior in both alkane hydroxylations andhydroperoxide decompositions.

Oxidation and Hydroperoxide Decomposition Methods

The invention is particularly useful for partially oxidizing alkanes toalcohols by contacting the alkane feedstock with oxygen and a transitionmetal complex of a porphyrin produced by the method of the invention.The feedstocks and operating conditions used in such operations aregenerally those described in U.S. Pat. Nos. 4,803,187; 4,859,798;4,895,680; 4,895,682; 4,900,871; 4,970,348 and 5,091,354, thedisclosures of which are hereby incorporated by reference.

The invention also provides a novel method for decomposinghydroperoxides to alcohols by contacting the hydroperoxide feedstockwith oxygen and such transition metal complex. The feedstocks andprocess conditions used in such operation according to the invention aregenerally as set forth in Lyons and Ellis U.S. Pat. No. 5,120,886, thedisclosure of which is hereby incorporated by reference.

The following examples illustrate the invention:

EXAMPLE 1 Synthesis of bis(pyrrol-2-yl)trifluoromethylmethane frompyrrole and trifluoroacetaldehyde methyl hemiacetal

Pyrrole (150 mmol) and trifluoroacetaldehyde methyl hemiacetal (75 mmol)in tetrahydrofuran are heated at reflux with catalytic amounts ofhydrochloric acid for 2 hours under an inert atmosphere. GC analysis ofthe reaction mixture indicated the presence of the desireddipyrromethane in greater than 80% yield. Neutralization of the acidfollowed by work up and chromatography gave the purebis(pyrrol-2-yl)-trifluoromethylmethane 3 (R³ =CF₃)). MS:m/z=214. Thispreparation has been disclosed in Wijesekera U.S. patent applicationSer. No. 08/143,261 filed on Oct. 26, 1993.

EXAMPLE 2 Synthesis of5,15-bis(pentafluorophenyl-10-20-bis-(trifluoromethyl)-porphyrin frombis(pyrrol-2-yl)trifluoromethylmenthane and pentafluorobenzaldehyde

Bis(pyrrol-2-yl)-trifluoromethylmethane (3; R³ =CF₃ ; R¹ =R² =R⁴ =R⁵ =H;1.07 g; 5 mmol) and pentafluorobenzaldehyde (4;R⁴ =perfluorophenyl; 982mg; 5 mmol) and hydrobromic acid (32% in acetic acid; 1 mL) were stirredin degassed chloroform (1 L) for 20 h at room temperature in the darkunder a closed argon atmosphere. The intermediate porphyrinogen wastreated with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and stirredfor 3 h exposed to light and air. The crude reaction mixture wasevaporated to dryness, the residue redissolved in chloroform andfiltered through neutral alumina which retains excess oxidant and mostof the byproducts. The pure product,5,15-bis(pentafluorophenyl)-10,20-bis(trifluoromethyl)porphyrin, or (C₆F₅)₂ (CF₃)₂ PH₂ where P designates the porphryinato ligand (5a;R¹ =R²=R⁴ =R⁵ =H, R³ =CF₃, R⁶ =C₆ F₅, M=2H), was obtained by evaporation ofthe filtrate to dryness and recrystallization of the residue fromdichloromethane/methanol. MS:m/z=778; uv: λ max 408, 504, 538, 584, 638.

EXAMPLE 3 Preparation of the iron complex of5,15-bis(pentafluorophenyl)-10,20-bis-(trifluoromethyl)porphyrin.

The porphyrin 5a prepared in Example 2 (200 mg), sodium acetatetrihydrate (600 mg) and glacial acetic acid (90 mL) were degassed andheated with ferrous chloride (600 mg) for 20 min at 100° C. The reactionmixture was allowed to cool to room temperature and exposed to airovernight. Hydrochloric acid (3M;90 ML) was added to the reactionmixture and the precipitated solid was filtered and washed with water.The solid was redissolved in chloroform and chromatographed on neutralalumina. The iron complex was eluted using 2% CH₃ OH-CH₂ Cl₂. Treatmentwith hydrochloric acid (6M) produced the desired product,5,15-bis(pentafluorophenyl)-10,20-bis(trifluoromethyl)porphyrinatoiron(III)chloride, or (C₆ F₅)₂ (CF₃)₂ PFeCl (5b; R¹ =R² =R⁴ =R⁵ =H, R³=CF₃, R⁶ =C₆ F₅, M=FeCl. MS: m/z=867 (M+),832 (M+-Cl); UV: λ max,350/408 (split Soret), 508(wk), 622(wk) nm.

EXAMPLE 4 Preparation of oxo-bridged dimer of iron complex of5,15-bis(penta-fluorophenyl-10,20-bis-(trifluoromethyl)porphyrin

The iron complex 5b prepared in Example 3 (100 mg) dissolved in toluene(50 mL) was stirred with aqueous sodium hydroxide (2M;50 ml) for 30 min.The organic layer was separated, washed with water (2×40 mL),concentrated and passed through neutral alumina (Brockman activity V).The eluate was evaporated to dryness to give the oxo-bridged dimer [(C₆F₅)₂ (CF₃)₂ PFe]₂ O (5c; R¹ =R² =R⁴ =R⁵ =H, R³ =CF₃, R⁶ =C₆ F₅,M=Fe-O-FeP) FABMS:m/z=1680 (M+), 832(M+-OFeP); UV: λ max, 332(wk),388(Soret), 422(sh),562,602 nm.

EXAMPLE 5 Preparation of azide derivative of iron Complex of5,15-bis(penta-fluorophenyl-10,20-bis-(trifluoromethyl)porphyrin

The iron complex 5b prepared in Example 3 (43 mg) dissolved in dryacetone (6 mL) was stirred with sodium azide (45 mg) for 45 h. The solidwas filtered and the filtrate was evaporated to dryness. The residue wasredissolved in dry dichloromethane, filtered and the solvent removed toisolate the azide derivative (C₆ F₅)₂ (CF₃)₂ PFeN₃ (5d; R¹ =R² =R⁴ =R⁵=H, R³ =CF₃, R⁶ =C₆ F₅, M=FeN₃) exhibiting a characteristic azidestretching frequency in the IR spectrum at 2042 cm-1.

EXAMPLE 6

Synthesis of 5,10,15,20-tetrakis(trifluoromethyl)porphyrin frombis-(pyrrol-2-yl)trifluoromethylmethane and trifluoroacetaldehyde methylhemiacetal

Equimolar quantities of bis(pyrrol-2-yl)-trifluoromethylmethane (3; R¹=R² =R^(4=R) ⁵ =H, R³ =CF₃) and trifluoroacetaldehyde methyl hemiacetal(4; R⁶ =CF₃ as the hemiacetal) were heated at reflux for 8 h in degassedchloroform in the presence of catalytic amounts of trifluoroacetic acid.The solution was allowed to cool to room temperature and treated,dropwise with a solution of 2,3-dichloro-5,6-dicyano-4-benzoquinone(DDQ) in benzene over 15 min. The reaction mixture was reheated atreflux for 3 h, cooled to room temperature and the porphyrin (CF₃)₄ PH₂(5e; R¹ =R² =R⁴ =R⁵ =H, R³ =R⁶ =CF₃, M=2H) isolated by passing throughneutral alumina. MS:m/z=582 (M+). UV: λ max, 404 (Soret), 510, 544, 594,648 nm.

EXAMPLE 7 Preparation of the iron complex of5,10,15,20-tetrakis(trifluoromethyl)-porphyrin

The porphyrin 5e prepared in Example 6 (30 mg), sodium acetatetrihydrate (100 mg) and acetic acid (12 mL) were degassed and heatedwith ferrous chloride (150 mg) for 20 min at 120° C. The reactionmixture was allowed to cool to room temperature and exposed to airovernight. Hydrochloric acid (3M) was added to the reaction mixture andthe precipitated solid filtered and washed with 2M HC1. The solid wasredissolved in chloroform, the solution extracted once with 6N HC1, theorganic layer separated and evaporated to dryness. The product,5,10,15,20-tetrakis(trifluoromethyl)porphyrinatoiron(III) chloride, or(CF₃)₄ PFeCl (5f; R¹ =R² =R⁴ =R⁵ =H, R^(3=R) ⁶ =CF₃, M=FeCl) wasisolated by redissolving in dichloromethane and crystallizing fromn-hexane. UV: 348/404 (split Soret), 506(wk), 640(wk) nm. MS: m/z,671/673 (M+), 636 (M-Cl).

EXAMPLE 8 Synthesis of 5,15-bis(trifluoromethyl)porphyrin frombis(pyrrol-2-yl)trifluoromethylmethane and dimethoxymethane

Equimolar quantities of bis(pyrrol-2-yl)-trifluoromethylmethane (3; R¹=R² =R⁴ =R⁵ =H, R³ =CF₃) and dimethoxymethane (4; R⁶ =H as the dimethylacetal), were refluxed for 3 h in degassed chloroform with catalyticamounts of hydrobromic acid. The cooled reaction mixture was stirredwith a solution of DDQ in benzene overnight, passed through neutralalumina (Brockman activity V) to isolate the porphyrin (CF₃)₂ PH₂ (5 g;R¹ =R² =R⁴ =R⁵ =R⁶ =H, R³ =CF₃, M=2H- MS:m/z=446(M+), UV: λ max,396(Soret), 498,534,576,626 nm.

EXAMPLE 9 Partial Oxidation of Isobutane with Oxo-Bridged Dimer of theIron Complex of5,15-bis(pentafluorophenyl-10,20-bis(trifluoromethyl)-porphyrin as theCatalyst

The catalyst [(C₆ F₅)₂ (CF₃)₂ PFe]₂ O prepared in Example 4 (5c;0.0065mmol) was dissolved in benzene (25 mL) and isobutane (7 g) added. Oxygen(5 bars) was pressed on the stirred solution at 60° C. for six hours.After this time, the solution was cooled, brought to atmosphericpressure and analyzed by standardized glpc. It was determined that 530moles of isobutane had reacted per gram-atom of iron used in thecatalyst. The selectivity to tert-butyl alcohol was over 85% withacetone and di-tert-butylperoxide being minor products.

EXAMPLE 10

Repeat of Example 9 with Higher Reaction Temperature

A catalytic reaction was run under the conditions of Example 9 exceptthat the reaction temperature was 80° C. Under these conditions, 1270moles of isobutane reacted per gram-atom of iron used and tert-butylalcohol was the predominant product.

EXAMPLE 11 Partial Oxidation of Isobutane with Azide Derivative of IronComplex of5,15-bis(pentafluorophenyl-10,20-bis-(triflucromethyl)porphyrin

A catalytic reaction was run under the conditions of Example 10 exceptthat the catalyst used was (C₆ F₅)₂ (CF₃)₂ PFeN₃ (5d;0.013 mmole)prepared in Example 5. Over 1330 moles of isobutane reacted pergram-atom of iron used and tert-butyl alcohol was the predominantproduct.

EXAMPLE 12 Comparison Example using unhalogenated metalloporphyrincomplexes

To illustrate the high activity of the above complexes relative tounhalogenated metalloporphyrin complexes, experiments were conductedunder the conditions of Example 11 except that the catalyst wasmeso-tetraphenylporphyrinatoiron(III) chloride [Fe(TPP)Cl] oroctaethylporphyrinatoiron(III) chloride [Fe(OEP)Cl] oroctaethylporphyrinatoiron(III) azide [Fe(OEP)N₃ ], and no reactionoccurred in any of the three cases.

EXAMPLE 13 Decomposition of Hydroperoxide Using the Catalyst of Example3

The complex (C₆ F₅)₂ (CF₃)₂ PFeCl prepared in Example 3 (5b, 0.6 mg) wasdirectly added to a stirring solution of tert-butylhydroperoxide (TBHP,13.8 g) in tert-butyl alcohol (TBA, 18.1 g) at 80° C. Oxygen was rapidlyevolved and the TBHP converted largely to TBA. Oxygen evolution wasmonitored manometrically with time. After a four hour reaction period,the reaction mixture was analyzed by standardized glpc. The TBHPconversion level was 97%. Product selectivities were: TBA (90%), acetone(5.1%) and di-tert-butylperoxide DTBP (2.4%).

EXAMPLE 14

Decomposition of Hydroperoxide Using Catalyst of Example 4

A reaction was run under conditions of Example 13 except that thecatalyst used was [(C₆ F₅)₂ (CF₃)₂ PFe]₂ O (5c) prepared in Example 4.After a 3.5 hour reaction period, the TBHP conversion level had reached96% and the product selectivities were: TBA (88%), acetone (6.2%) andDTBP (2.6%).

EXAMPLE 15 Comparison Decomposition of Hydroperoxide Using UnhalogenatedComplex as Catalyst

To illustrate that the complexes of Examples 13 and 14 have exceptionalactivity, a reaction was run under conditions of Example 13, except thatthe catalyst was the unhalogenated complex, Fe(OEP)Cl. Very slow oxygenevolution was observed and after a 3.7 hour reaction period, the TDHPconversion level had reached only 11%. Furthermore, the catalyst hadbecome completely inactive.

EXAMPLE 16 Synthesis of5,15-bis(pentafluorophenyl)-10,20-bis(tribluoromethyl)-β-OCTABROMOPORPHYRINATOIRON(III)chloride

5,15-bis(pentafluorophenyl)-10,20-bis(trifluoromethyl)-porphyrinatoiron(III)chloride 5b, prepared in Example 3 (110 mg) is placed in dry carbontetrachloride (40 mL) and pyridine (2 mL) and heated to reflux. Asolution of bromine (0.5 mL) in carbon tetrachloride (2 mL) is added andcontinued heating at reflux for 10 h. The solution is allowed to cool toroom temperature and the supernatant solution decanted. The residue isdissolved in 6M hydrochloric acid, washed with chloroform. The combinedorganic layers are extracted with 6M hydrochloric acid followed by 2Maqueous sodium hydroxide, washed with water and evaporated to dryness.The residue is dissolved in chloroform, the solution filtered through apad of aluminal (neutral) and evaporated to dryness to give the titlecompound.

EXAMPLE 17

Synthesis of5,10,15,20-tetrakis(trifluoromethyl)-β-octabromoporphyrinatoiron(III)chloride

5,1-0,15,20-tetrakis(trifluoromethyl)porphyrinatoiron(III) chloride 5fas prepared in Example 7, is β-brominated as described in Example 16 togive the analogous β-brominated derivative.

The invention claimed is:
 1. Composition of matter having the followingstructural formula: ##STR4## where M is a metal with or without halide,hydroxide or azide or with or without an oxo bridge form an oxo-bridgeddimer, where said metal is iron, manganese, cobalt or ruthenium and (a)R⁶ is hydrogen or haloaryl, R³ is hydrogen or haloalkyl, but R⁶ and R³are not both hydrogen, and where R¹, R², R⁴ and R⁵ are independentlyhydrogen, hydrocarbyl, halogen, nitro, cyano or halocarbyl, or (b) R³ ishaloalkyl and R⁶ is haloalkyl but R³ and R⁶ are not the same haloalkyl,and R¹, R², R⁴ and R⁵ are halogen.
 2. Composition of matter according toclaim 1 wherein R⁶ is hydrogen and R³ is haloalkyl.
 3. Composition ofmatter according to claim 2 wherein R³ is perfluoroalkyl.
 4. Compositionof matter according to claim 1 wherein R⁶ is haloaryl and R³ ishydrogen.
 5. Composition of matter according to claim 4 wherein R⁶ isperfluoroaryl.
 6. Composition of matter according to claim 1 wherein R⁶is pentafluorophenyl and R³ is trifluoromethyl.
 7. Composition of matteraccording to claim 1 wherein R³ and R⁶ are haloalkyl and R¹, R², R⁴ andR⁵ are halogen.
 8. Composition of matter according to claim 7 wherein R³and R⁶ are perfluoroalkyl and said halogen is bromine.
 9. Composition ofmatter according to claim 7 wherein R³ and R⁶ are perfluoroalkyl andsaid halogen is chlorine.
 10. Composition comprising an oxo-bridgeddimer of claim
 1. 11. Composition comprising an azide of claim
 1. 12.Composition of matter according to claim 1 wherein M is iron. 13.Composition of matter according to claim 12 wherein said iron is presentas iron(III)halide.